Is there a Problem in taking Trazodone as a sleep aid, and cymbalta for depression:?
Wednesday, November 18th, 2009 at
2:34 pm
I have depression, and imsomnia, but i was prescribed trazodone as a sleep aid, and cymbalta for depression, is there any very bad side effects by taking both, cymbalta in te morning , 20 mg and tradozone at night. 50 mg, . Thank you.
Filed under: Insomnia
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There is a potential for a major drug-drug interaction with these two medicines.
Cymbalta (duloxetine) is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs).
The mechanism of Trazodone HCl’s antidepressant action in man is not fully understood. In animals, Trazodone HCl selectively inhibits its serotonin uptake by brain synaptosomes and potentiates the behavioral changes induced by the serotonin precursor, 5-hydroxytryptophan.
Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John’s wort, phenylpiperidine opioids, dextromethorphan, and 5-hydroxytryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious condition thought to result from hyperstimulation of brainstem 5-HT1A receptors.
In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. Particular caution is advised when increasing the dosages of these agents as well.
Ask your Doctor or Pharmacist.